Formulation and Evaluation of Solid Dispersion Technique of Poorly Water Soluble Drug Atenolol
Keywords:
Solid dispersion, Atenolol, PEG 6000, HPMC (E4), Dissolution, SolubilityAbstract
The objective of present study was to improve the aqueous solubility and dissolution rate of poorly water-soluble drug Atenolol by solid dispersion technique. The method of preparation used was Hot Melt Method and Kneading Method using a carrier polyethylene glycol 6000 (PEG 6000), and hydroxyl propyl methyl cellulose (HPMC E4). The study was further aimed to characterize prepared solid dispersions in the solid state by Fourier Transform Infrared Spectroscopy (FTIR). Dissolution studies were carried out to find out percentage released content of drug as a function of time, UV-visible spectroscopy method was used to find out drug contents in all the samples.
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