Sustained Release Tablet using combination of Hydrophilic and Hydrophobic Polymers
Keywords:
Ambroxol Hydrochloride, Sustained release, HPMC K 100, Ethyl cellulose, Eudragit S 100Abstract
The sustained release tablet of Ambroxol Hydrochloride were prepared and evaluated by emphasizing on the effect of hydrophilic polymer like HPMCK100, Eudragit S100 and hydrophobic polymer Ethyl cellulose which are used as matrices to control the drug release . The polymer were used alone and as in combination. Tablets containing the drug were prepared by direct compression with different drug polymer ratio.The tablet were evaluated for thickness, weightt variation test, drug content, hardness, friability and in-vitro drug release studies. In- vitro drug release studies from the prepared matrix tablets were conducted for a period of 12 hrs using an USP dissolution test apparatus (type II Paddel) at 37±0.50C and 50 rpm. The optimized formulation F11(1:1:1) showed 92.61%drug release in 12 hrs .The release kinetics was analyzed using Korsmeyer- Peppas model which present the maximum regression coefficient value (0.9916)with anamolous release mechanism. The optimized formulation F11 was kept for short term stability study at room temperature and with relative humidity of 75% ,the stability study of formulation F11showed no significant changes.
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