Formulation and Evaluation of Fast Mouth Dissolving Film of Tenofovir Disoproxil Fumarate
Keywords:
Tenofovir Disoproxil Fumarate, Mouth-dissolving film, HPMC E15, PEG-400, Solvent Casting MethodAbstract
Mouth dissolving dosage forms are gaining popularity in recent time because of good patient compatibility, fast disintegration time, flexibility in transportation etc. In this research work Tenofovir Disoproxil Fumarate (TDF) is used to treat chronic hepatitis B. TDF is an antiretroviral drug. TDF is selected as model drug for the preparation of Mouth dissolving film (MDF). MDF was prepared by solvent casting method using HPMC E15 & PVP K30 as film former and Glycerol & PEG-400 as plasticizers. MDF were evaluated for physical characteristics such as tensile strength, percentage elongation, drug content uniformity, surface pH, folding endurance, uniformity weight, and thickness and gave satisfactory result. The formulations were subjected to disintegration time, in vitro drug release test and stability study. The FTIR studies revealed that there was no physicochemical interaction between excipients and drug. The FTIR studies revealed that there was no physicochemical interaction between excipients and drug. A marked % drug release was exhibited by MDF of TDF containing HPMC E15 as a polymer at 30 sec.
References
[1] Nishi Thakur, MayankBansal, Neha Sharma, PragatiKhare. Overview: A novel approach of fast dissolving films & their patents.Advance in biological research.2013, vol7, issue (3):50-58.
[2] SwapnilL.Patil, PareshR.Mahaparale, MadhaviA.Shivnikar, Shradha S. Tiwary, Ketan V. Pawar, PrashantN.Sane. Fast dissolving oral films: An innovative drug delivery system. International journal of drug discovery & medical research.2012, (1):39-43.
[3] SubashVijaya Kumar, BasaniGavskar, Gurusharan.Overview on fast dissolving film. International journal of pharmacy and pharmaceutical science.2010, vol 2, issue (3):29-33.
[4] RavneetKaur, RajniBala, Dhruvmalik. A novel approach in oral fast dissolving drug delivery system a review. American journal of pharmatech research .2012, vol2, issue (1):88-104.
[5] Indian Pharmacopoeia,Vol.II. Government of India, Ministry of health and family welfare, Delhi Controller of publications; 1996;10341035
[6] United State Pharmacopoeia 24, NF 19, Asian ed,Rockvilled: United state Pharmacopoeialcovention; 2004;1623-1624
[7] PatilChandrashekhar B, Reddy Suyodhana, KulkarniUpendra, PatilBaswaraj, SoodamSrinivas R. Design and development of fast dissolving Tizanidine tablet by sublimation Technique for the effective treatment of muscle spasm. International journal of research and pharmacy. 2011, vol 2, issue (2):541-543.
[8] Ulrich Siemann. Solvent cast technology-a versatile tool for thin film production. Proger colloid poly sci.2005, vol 130:1-14.
[9] SeemaSaini, Samta, A. C. Rana and SunitGupta.Optimization of formulation of fast dissolving films made of pullulan polymer.
International journal of pharmaceutical science review & research. 2011, vol 9, issue (1):127-131.
[10] K.Shivanand, S.A. Puja, B. Jaykar. Mucoadhesive bilayeredbuccal tablet of Tizanidine HCL. International journal of pharma tech research.2010, vol 2, issue (3):1861-1869.
[11] NarasimhaRao R, Shindu Reddy Kandhadi, Swapna D, Sushma Devi Konasree, SwathiEnugala. Formulation & evaluation of rapidly dissolving buccal patches. International journal of pharmacy & biological sciences.2011, vol 1, issue (3):145-159.
[12] PanditMihir, Gandhi Nirvi, BondeSmita, PandyaSudhir. Formulation development & evaluation of quikcly dissolving oral strip containing Sumatriptan Succinate. International research journal of pharmacy.2012, vol 3, issue (11):216-219.
[13] VijaykumarGhorwade, AjaykumarPatil, SatishkumarPatil. Priya Patel. Development & evaluation of fast dissolving film of montelukast sodium. World journal of medical pharmaceutical & biological sciences. 2011, vol 1, issue (1); 6-12.
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